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Fast disintegrating tablets containing Rhodiola rosea L. extract
Agne Kucinskaite1, Wiesław Sawicki, Vitalis Briedis
1Department of Pharmaceutical Technology and Social Pharmacy, Kaunas University of Medicine, A. Mickeviciaus 9, 44307 Kaunas, Lithuania.
Acta Poloniae Pharmaceutica
|August 2, 2007
Summary
Fast-dissolving Rhodiola rosea L. tablets were developed using specific fillers and extract ratios. Optimal formulations achieved rapid disintegration, but stability varied under different storage conditions, impacting tablet hardness.
Area of Science:
- Pharmacognosy
- Pharmaceutical Technology
Background:
- Rhodiola rosea L. is a medicinal plant with potential therapeutic benefits.
- Developing stable and rapidly disintegrating oral dosage forms is crucial for drug delivery.
Purpose of the Study:
- To develop 250 mg tablets of Rhodiola rosea L. extract with disintegration times under 10 minutes.
- To evaluate the impact of extract concentration, fillers, and disintegrants on tablet properties.
Main Methods:
- Formulation of tablets with varying Rhodiola rosea L. extract concentrations.
- Assessment of disintegration time, tablet hardness, and stability under controlled conditions.
- Analysis of the influence of microcrystalline cellulose, povidone, and crospovidone.
Main Results:
- Tablet disintegration time was primarily determined by the filler type and extract:filler ratio, not the disintegrant.
- An extract:filler ratio below 1:1.5 ensured rapid disintegration.
- Tablets were stable for 6 months at 25°C/60% RH but showed decreased hardness at 40°C/75% RH.
Conclusions:
- Formulation parameters, specifically the filler and extract ratio, are critical for achieving fast-dissolving Rhodiola rosea L. tablets.
- While initial stability is good, elevated temperature and humidity negatively affect tablet hardness, indicating potential shelf-life limitations.
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