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Related Experiment Videos

Enhancing cell longevity for cosmetic application: a complementary approach.

Marielle Moreau1, Michèle Neveu, Sandrine Stéphan

  • 1LVMH Recherche - Parfums Christian Dior, St. Jean de Braye, France.

Journal of Drugs in Dermatology : JDD
|August 19, 2007
PubMed
Summary
This summary is machine-generated.

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Yeast Kluyveromyces biopeptides boost sirtuin 1 (SIRT1) expression in skin cells, enhancing DNA resistance and reducing senescence. A skincare product with these biopeptides effectively improved multiple signs of skin aging.

Area of Science:

  • Biochemistry
  • Dermatology
  • Cell Biology

Background:

  • Cell longevity is associated with sirtuins (silent information regulators), enzymes crucial for gene silencing, apoptosis, and metabolism.
  • Sirtuins optimize cellular functions, particularly in skin cells facing environmental stressors.
  • This study investigates yeast Kluyveromyces biopeptides' role in sirtuin stimulation and their skin benefits.

Purpose of the Study:

  • To evaluate the effect of yeast Kluyveromyces biopeptides on sirtuin expression in human skin cells.
  • To assess the efficacy of a skincare product containing these biopeptides in improving signs of skin aging.

Main Methods:

  • Investigated Silent mating type information regulation 2 homolog 1 (SIRT1) using immunostaining, Western blotting, and cytometry in human skin cells and ex vivo samples.

Related Experiment Videos

  • Assessed cellular integrity and aging via comet assays (DNA fragmentation) and beta-galactosidase activity.
  • A formulation with 1% yeast biopeptides was applied daily for 4 weeks by 33 female subjects; skin parameters were evaluated clinically and objectively using the Pixel Skin method.

    • Main Results:

    • Yeast Kluyveromyces biopeptides significantly increased SIRT1 expression in vitro (+172%) and ex vivo.
    • Reduced UVB-induced cell senescence and DNA fragmentation.
    • Demonstrated significant improvements in fine lines, wrinkles, hydration, pigmentation, radiance, firmness, homogeneity, and texture, with immediate hydration improvement after first use.

    Conclusions:

    • Yeast Kluyveromyces biopeptides effectively activate SIRT1 in human skin cells.
    • These biopeptides enhance DNA resistance and reduce skin cell senescence.
    • The tested formulation significantly treats multiple signs of skin aging.