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Updated: Jul 13, 2026

Electrophoretic Analysis of Replication Through Structure-Prone DNA Repeats Within the SV40-Based Human Episome
Published on: September 13, 2024
Comparison of DNA replication in Xenopus laevis and Simian Virus 40
Maren Oehlmann1, Cathal Mahon, Heinz-Peter Nasheuer
1Department of Biochemistry, National University of Ireland, Galway, Ireland. maren.oehlmann@nuigalway.ie
Abstract:
DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: origin-licensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and lagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).
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