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08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Mitoses in conventional melanocytic nevi.
Sarah L Jensen1, Arash Radfar, Jag Bhawan
1Division of Dermatopathology, Department of Dermatology, Boston University, Boston, MA, USA. sjensen@im.wustl.edu
Journal of Cutaneous Pathology
|August 19, 2007
Summary
Occasional mitotic figures can be found in conventional melanocytic nevi. This study found mitoses in 4% of unremarkable nevi, indicating they can occur in benign lesions.
Area of Science:
- Dermatopathology
- Cell Biology
Background:
- Melanocytic nevi are common skin lesions.
- Nevi can exhibit growth, suggesting cell division may occur.
Purpose of the Study:
- To determine the frequency of mitotic figures in conventional melanocytic nevi.
- To investigate the characteristics associated with mitotic figures in nevi.
Main Methods:
- Literature review on mitotic figures in nevi.
- Histopathological review of 157 conventional nevi.
- Analysis of mitotic figure location and associated features.
Main Results:
- Mitotic figures were identified in 7 out of 157 (4%) of the reviewed nevi.
- The location and presence of congenital features or inflammation were noted.
- Occasional mitoses were observed in otherwise unremarkable nevi.
Conclusions:
- Mitotic figures can be present in conventional, unremarkable melanocytic nevi.
- The finding of occasional mitoses does not necessarily indicate malignancy.
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