Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Advance of study on Mer function].

Lei Fan1, Chang-Geng Ruan

  • 1Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|August 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Preparation and Application of Monoclonal Antibody Against Human von Willebrand Factor Propeptide].

Zhongguo shi yan xue ye xue za zhi·2023
Same author

[Application of Bionano-DNA Full-Length Optical Mapping Technology in Genetic Diagnosis of Hemophilia A Carriers].

Zhongguo shi yan xue ye xue za zhi·2023
Same author

[Recent Advances in SARS-CoV-2-Induced Immune Thrombocytopenia --Review].

Zhongguo shi yan xue ye xue za zhi·2023
Same author

[The Effect of VWF Propeptide on VWF Mutant in D1 Domain].

Zhongguo shi yan xue ye xue za zhi·2022
Same author

Bifunctional effect of the inflammatory cytokine tumor necrosis factor α on megakaryopoiesis and platelet production.

Journal of thrombosis and haemostasis : JTH·2022
Same author

[Clinical Significance of Pretransplant Serum Ferritin Level in Patients with Prolonged Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation].

Zhongguo shi yan xue ye xue za zhi·2021
Same journal

[Research Progress on the Bone Marrow Microenvironment in Beta-Thalassemia --Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same journal

[Research Progress of CAR-T Cell Therapy in Autoimmune Diseases --Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same journal

[Research Progress of Chimeric Antigen Receptor T Cell Therapy in Acute Myeloid Leukemia--Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same journal

[Research Progress in Venetoclax-Based Combination Therapy in Acute Myeloid Leukaemia--Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same journal

[Advances in the Treatment of Acute Myeloid Leukemia with <i>TP53</i> Mutations-Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same journal

[Analysis of Risk Factors and Clinical Characteristics of Early Death in Patients with Hemophagocytic Syndrome].

Zhongguo shi yan xue ye xue za zhi·2026
See all related articles

Mer receptor tyrosine kinase, activated by its ligand Gas6, plays roles in inflammation, apoptosis, and thrombosis. Recent advances in Mer function were reviewed, discussing its potential for antithrombosis and antitumor therapies.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Mer is a receptor tyrosine kinase in the Axl family.
  • Its ligand, Gas6, activates Mer signaling.
  • Mer is implicated in critical cellular processes like inflammation, apoptosis, tumorigenesis, thrombosis, and hemostasis.

Purpose of the Study:

  • To review recent advancements in understanding Mer receptor tyrosine kinase function.
  • To discuss the therapeutic potential of targeting Mer for antithrombosis and antitumor applications.

Main Methods:

  • Literature review of recent studies on Mer receptor tyrosine kinase.
  • Analysis of Mer's role in various biological pathways.
  • Discussion of preclinical and clinical data related to Mer-targeted therapies.

Related Experiment Videos

Main Results:

  • Mer signaling is crucial for regulating inflammation, apoptosis, and thrombosis.
  • Dysregulation of Mer is linked to tumorigenesis.
  • Targeting Mer shows promise in preclinical models for antithrombosis and antitumor effects.

Conclusions:

  • Mer receptor tyrosine kinase is a significant regulator of multiple cellular functions.
  • Further research into Mer signaling pathways could yield novel therapeutic strategies for thrombosis and cancer.