Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal arterial macroaneurysm rupture in a 17-year-old: Could cannabis consumption be a risk factor?

Journal francais d'ophtalmologie·2025
Same author

[Contemporary refractive surgical procedures].

Revue medicale de Bruxelles·2015
Same author

Macular CMV retinitis: a case report.

Bulletin de la Societe belge d'ophtalmologie·2004
Same author

[Analysis of optical coherence tomography for macular hole closure after surgery].

Bulletin de la Societe belge d'ophtalmologie·2003
Same author

Infliximab in patients with primary Sjögren's syndrome: a pilot study.

Arthritis and rheumatism·2001
Same author

[Vitrectomy for diabetic macular edema associated with hyaloid posterior traction].

Bulletin de la Societe belge d'ophtalmologie·2000

Related Experiment Video

Updated: Jul 12, 2026

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

[Intravitreal injections of corticoids].

P Demols1

  • 1Service d'Ophtalmologie, Hôpital Erasme, Université Libre de Bruxelles, Bruxelles. paul.demols@erasme.ulb.ac.be

Bulletin De La Societe Belge D'Ophtalmologie
|August 28, 2007
PubMed
Summary

Intravitreal injections of triamcinolone acetonide are common for eye diseases but carry risks. Careful patient selection and monitoring are essential to manage potential complications.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Retinal Diseases

Context:

  • Intravitreal injections of triamcinolone acetonide are a prevalent treatment for diverse ocular conditions.
  • The potential toxicity of the corticosteroid and its delivery vehicle necessitates ongoing investigation.

Purpose:

  • To highlight the established therapeutic applications of intravitreal triamcinolone acetonide.
  • To underscore the inherent risks and known complications associated with this treatment modality.

Summary:

  • Common complications include elevated intraocular pressure, cataract formation, and severe outcomes like endophthalmitis, vitreous hemorrhage, and retinal detachment.
  • These adverse events are linked to both the pharmacological agent and the injection technique itself.

More Related Videos

Intracameral Injection in Rats with Low Risk of Adverse Effects
06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Jul 12, 2026

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Intracameral Injection in Rats with Low Risk of Adverse Effects
06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Impact:

  • Emphasizes the critical need for meticulousness in prescribing, administering, and monitoring intravitreal triamcinolone acetonide injections.
  • Promotes safer patient outcomes by advocating for rigorous clinical practice standards.