Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environmental perchlorate: why it matters.

Andrea B Kirk1

  • 1Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA. a.kirk@ttu.edu

Analytica Chimica Acta
|August 29, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A New Interpretation of Relative Importance on an Analysis of Per and Polyfluorinated Alkyl Substances (PFAS) Exposures on Bone Mineral Density.

International journal of environmental research and public health·2023
Same author

Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants.

International journal of environmental research and public health·2022
Same author

PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARγ.

Endocrinology·2021
Same author

Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review.

International journal of environmental research and public health·2021
Same author

Relative source contributions for perchlorate exposures in a lactating human cohort.

The Science of the total environment·2012
Same author

Breastfed infants metabolize perchlorate.

Environmental science & technology·2012
Same journal

Programmable DNA probe-mediated nanopore biosensor for multiplex nucleic acid detection and its application in milk authenticity identification.

Analytica chimica acta·2026
Same journal

A multifunctional fluorescent sensor for sequential off-on-off visual detection of Zn<sup>2+</sup> and glyphosate in food and biological matrices and efficient removal of Zn<sup>2+</sup> from aqueous media.

Analytica chimica acta·2026
Same journal

Automated carousel-based electrochemical sensing toward microbiological and oncological settings.

Analytica chimica acta·2026
Same journal

Label-free quantification of cumulative cytosol-enriched peptide concentrations by mass spectrometry.

Analytica chimica acta·2026
Same journal

Integrated multi-matrix bile acid metabolic metrics (BAMMs): A methodological framework for functional metabolic phenotyping in human subjects.

Analytica chimica acta·2026
Same journal

A dual-enzymatic activity/SERS dual-mode sensor array based on BSA-Cu nanoflowers for sensitive detection of various foodborne pathogens.

Analytica chimica acta·2026
See all related articles

Perchlorate toxicity interferes with iodide uptake, crucial for thyroid hormone (TH) production. This can harm infant neurodevelopment, but human exposure levels and risks remain unknown.

Area of Science:

  • Environmental Toxicology
  • Neurodevelopmental Science
  • Endocrinology

Background:

  • Perchlorate toxicity primarily occurs through inhibition of the sodium-iodide symporter (NIS).
  • NIS is essential for iodide uptake in the thyroid and mammary glands, impacting thyroid hormone (TH) synthesis and transfer to infants.
  • Adequate TH is critical for infant neurodevelopment, making early life a vulnerable period.

Purpose of the Study:

  • To review the potential adverse effects of perchlorate exposure on neurodevelopment.
  • To highlight the complexities in assessing perchlorate risks, including confounding factors.
  • To emphasize the critical need for quantifying human exposure to perchlorate.

Main Methods:

  • Literature review summarizing existing knowledge on perchlorate toxicity and NIS function.

Related Experiment Videos

  • Discussion of factors complicating risk assessment, such as maternal/fetal thyroid status and co-exposures.
  • Identification of knowledge gaps, particularly regarding quantified human exposure levels.

    • Main Results:

    • Perchlorate's mechanism of toxicity is well-defined as NIS inhibition, leading to potential hypothyroidism or hypothyroxinemia.
    • Adverse neurodevelopmental effects are most probable during early life due to TH dependency.
    • Significant uncertainties exist regarding the impact of current environmental perchlorate exposures on neurodevelopment.

    Conclusions:

    • Perchlorate exposure poses a potential risk to neurodevelopment, especially in infants.
    • Accurate risk assessment requires consideration of iodine intake and other co-exposures.
    • Quantifying human exposure to perchlorate is a critical, yet unresolved, issue for analytical chemistry and public health.