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Updated: Jul 12, 2026

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

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Published on: September 22, 2014

Cell therapy in congestive heart failure.

Ze-wei Tao¹, Long-gui Li

¹Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. taozw@hotmail.com

Journal of Zhejiang University. Science. B

|August 30, 2007

Summary

Congestive heart failure (CHF) research explores stem cell therapy. Bone marrow stem cells (BMCs) and cardiac stem cells (CSCs) show promise in animal models for heart repair, but clinical trial results are mixed.

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Published on: January 21, 2018

Area of Science:

Cardiology
Regenerative Medicine
Stem Cell Biology

Background:

Congestive heart failure (CHF) is a growing global epidemic.
Cardiomyocyte loss (necrosis and apoptosis) significantly contributes to CHF progression.
Exogenous cell implantation presents a potential therapeutic strategy for CHF.

Purpose of the Study:

To investigate the role of cardiac stem cells (CSCs) and bone marrow stem cells (BMCs) in heart repair.
To evaluate the efficacy of stem cell therapy in treating congestive heart failure.

Main Methods:

Studies involve observing CSC proliferation and BMC homing to injured cardiac tissue.
Preclinical studies utilize stem cell transplantation in animal models of CHF.
Clinical evaluation includes randomized, double-blind, placebo-controlled trials for BMC therapy.

Main Results:

Basic studies in animals show improved ventricular remodeling and heart function with BMCs and CSCs.
Clinical trials investigating BMC therapy for acute myocardial infarction have yielded inconsistent outcomes.
Stem cells may reconstitute CSC populations and differentiate into cardiac tissue.

Conclusions:

Stem cell therapy holds potential for treating CHF by promoting cardiac repair.
Further research and clinical trials are needed to clarify the efficacy and optimal application of stem cell therapies in heart failure.
The therapeutic benefits of BMCs in acute myocardial infarction require further investigation.