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Updated: Jul 11, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
Analysis of low molecular weight acids by negative mode matrix-assisted laser desorption/ionization time-of-flight
Rohit Shroff1, Alexander Muck, Ales Svatos
1Mass Spectrometry Research Group, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07745 Jena, Germany.
Abstract:
Free 9-aminoacridine base is demonstrated to be a suitable matrix for negative mode matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOFMS) analysis of a wide range of low molecular weight organic acids including aliphatic (from acetic to palmitic acid), aromatic acids, phytohormones (e.g. jasmonic and salicylic acids), and amino acids. Low limits of quantitation in the femtomolar range (jasmonic - 250 fmol; caffeic - 160 fmol and salicylic - 12.5 fmol) and linear detector response over two concentration orders in the pico- and femtomolar range are extremely encouraging for the direct study of such acids in complex biological matrices.
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