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[Intestinal microecology in some systemic connective tissue diseases].
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|September 22, 2007
Summary
Systemic connective tissue diseases alter gut microbiota, decreasing beneficial bacteria like Lactobacillus and increasing opportunistic pathogens. This shift, particularly pronounced in systemic scleriasis, impacts intestinal health and may contribute to disease progression.
Area of Science:
- Microbiology
- Immunology
- Rheumatology
Background:
- Systemic connective tissue diseases (SCTD) are autoimmune disorders affecting multiple organs.
- The gut microbiome plays a crucial role in immune system regulation and overall health.
- Alterations in gut microbiota composition have been implicated in various autoimmune conditions.
Purpose of the Study:
- To characterize the intestinal microflora in patients with systemic connective tissue diseases.
- To compare the gut microbial profiles of patients with systemic lupus erythematosus (SLE) and systemic scleriasis (SSc).
- To identify specific microbial changes associated with these autoimmune conditions.
Main Methods:
- Analysis of the species structure of intestinal microflora in patients with SCTD.
- Quantitative and qualitative assessment of bacterial populations, including anaerobic, opportunistic, Lactobacillus, Bifidobacterium, and Bacteroides species.
- Detection of opportunistic bacteria with hemolytic activity, Staphylococcus, Enterobacteriaceae, S. aureus, and Candida.
Main Results:
- A decrease in the dominance of anaerobic bacteria and an increase in opportunistic bacteria were observed.
- Significant reductions in Lactobacillus, Bifidobacterium, and Bacteroides were noted.
- Increased detection rates and colonization density of Staphylococcus, opportunistic Enterobacteriaceae, and S. aureus were found.
- Patients with systemic scleriasis showed a higher prevalence of opportunistic intestinal bacteria, Candida, and hemolytic microorganisms compared to SLE patients.
Conclusions:
- Systemic connective tissue diseases significantly disrupt the intestinal microflora, favoring opportunistic pathogens.
- The observed dysbiosis, characterized by reduced beneficial bacteria and increased harmful microbes, may be a contributing factor to disease pathogenesis.
- Systemic scleriasis exhibits a more pronounced colonization by opportunistic and potentially pathogenic microorganisms in the gut.
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