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Published on: July 19, 2018
The first weeks on peritoneal dialysis: effects on clinical parameters
Karima Farhat1, Frans J van Ittersum, Paolo Fabbrini
1Department of Nephrology, VU University Medical Center, Amsterdam, Netherlands. k.farhat@vumc.nl
Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|September 25, 2007
Summary
Initiation of peritoneal dialysis (PD) did not significantly alter weight or blood pressure in new patients. However, urine production and residual creatinine clearance decreased, with systemic inflammation markers higher in prior hemodialysis patients.
Area of Science:
- Nephrology
- Internal Medicine
Background:
- Peritoneal dialysis (PD) initiation causes local and systemic changes.
- Understanding early clinical and systemic responses to PD is crucial for patient management.
Purpose of the Study:
- To investigate early clinical and systemic changes in new peritoneal dialysis patients.
- To assess alterations in inflammation markers and residual renal function post-catheter insertion and early PD treatment.
Main Methods:
- Pilot study involving 11 new PD patients.
- Clinical parameters, laboratory tests, and systemic inflammation markers (hs-CRP) were monitored for 6 weeks post-catheter insertion.
- Patients received lactate-buffered dialysis solutions.
Main Results:
- No significant changes in patient weight or blood pressure were observed during the initial 6 weeks of PD.
- A significant decline in 24-hour urine production and daily residual creatinine clearance (CCr) was noted.
- High-sensitivity C-reactive protein (hs-CRP) levels were elevated in patients with prior hemodialysis history and decreased after transitioning to PD.
Conclusions:
- Early PD initiation does not significantly impact weight or blood pressure.
- A decline in residual renal function (urine production and CCr) occurs early in PD treatment.
- Systemic inflammation markers differ based on prior dialysis modality, suggesting PD may influence inflammatory status.
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