Related Experiment Video
Updated: Jul 11, 2026

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy (NMR) and Microscale Thermophoresis (MST)
Published on: November 2, 2018
Stripline probes for nuclear magnetic resonance
P J M van Bentum1, J W G Janssen, A P M Kentgens
1Institute for Molecules and Materials, Radboud University, Toernooiveld 1, 6525ED Nijmegen, The Netherlands.
A new stripline radiofrequency (RF) coil design for chip-integrated Nuclear Magnetic Resonance (NMR) analysis offers superior sensitivity and scalability. This innovative NMR tool promises high performance in a compact, lithographically defined structure.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Materials Science
Background:
- Conventional Nuclear Magnetic Resonance (NMR) spectroscopy often relies on bulky and complex RF coil systems.
- The development of miniaturized and integrated NMR systems is crucial for portable and high-throughput analysis.
- Planar RF coil designs offer potential advantages in terms of fabrication and integration.
Purpose of the Study:
- To evaluate a novel stripline RF coil design for chip-integrated NMR analysis.
- To assess the performance characteristics, including sensitivity and scalability, of the proposed planar coil.
- To investigate the suitability of the stripline coil for NMR measurements at high frequencies.
Main Methods:
- Design and simulation of a single-layer lithographic stripline RF coil.
- Detailed analysis of RF field strength, homogeneity, and susceptibility broadening.
- Simplified modeling of thermal effects relevant to integrated systems.
- Preliminary experimental validation using solid and liquid samples at 600 MHz.
Main Results:
- The stripline coil design is fully scalable to smaller dimensions using standard lithography.
- The planar structure demonstrates potential for superior sensitivity compared to conventional 3D helix coils.
- Preliminary NMR tests confirm the design's viability, showing good performance at 600 MHz.
- The design exhibits high power handling capabilities and low susceptibility broadening.
Conclusions:
- The stripline RF coil represents a promising advancement for chip-integrated NMR applications.
- Its scalability, high sensitivity, and robustness make it a valuable addition to the NMR analytical toolbox.
- This technology facilitates the development of more compact and efficient NMR spectrometers.
More Related Videos
12:47Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
Published on: December 27, 2016
14:55Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Related Concept Videos
Applications Of NMR In Biology
The...
Double Resonance Techniques: Overview
Spin decoupling is usually achieved by...
Nuclear Magnetic Resonance (NMR): Overview
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)
NMR Spectrometers: Resolution and Error Correction
Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule