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Updated: Jul 11, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

A wireless implantable multichannel microstimulating system-on-a-chip with modular architecture.

Maysam Ghovanloo¹, Khalil Najafi

¹GT Bionics Laboratory, Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. mghovan@ncsu.edu

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society

|September 27, 2007

Summary

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A new wireless microstimulator chip (Interestim-2B) and implant enable high-density neural stimulation for prosthetic applications. This technology supports up to 2048 sites, offering advanced control and monitoring for neural interfacing.

Area of Science:

Biomedical Engineering
Neuroscience
Electrical Engineering

Background:

Neural prosthetics require advanced stimulation systems for interfacing with neural tissue.
Existing systems often face limitations in site density, control, and monitoring capabilities.

Purpose of the Study:

To develop a high-density wireless microstimulator chip (Interestim-2B) and a prototype implant for neural prosthetic applications.
To enable precise and flexible neural stimulation with integrated monitoring features.

Main Methods:

Designed and fabricated the Interestim-2B chip using 1.5 microm CMOS technology.
Developed a modular architecture supporting up to 32 chips for 2048 stimulating sites.
Integrated off-chip components including an LC tank, low-pass filter, and microelectrode arrays.

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The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

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Last Updated: Jul 11, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

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Published on: September 27, 2018

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

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Implemented inductive power and data transfer (2.5 Mb/s FSK), generating up to 65,800 pulses/s.

Included 5-bit DAC resolution, 270 microA current drivers, and site potential/impedance measurement capabilities.

Main Results:

The Interestim-2B chip measures 4.6 x 4.6 x 0.5 mm, with a prototype implant size of 19 x 14 x 6 mm (shrinkable to < 0.5 cc).
The system supports arbitrary current waveforms, monopolar/bipolar protocols, and charge balancing.
Demonstrated in vitro and in vivo experimental results using the prototype implant.

Conclusions:

The Interestim-2B chip and prototype implant offer a scalable, high-density solution for neural stimulation.
Integrated monitoring features enhance the utility for chronic stimulation and diagnostics.
This technology holds significant potential for advancing neural prosthetic applications.