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Chemometric experimental design based optimization techniques in capillary electrophoresis: a critical review of
Grady Hanrahan1, Ruthy Montes, Frank A Gomez
1Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, CA 90032, USA. ghanraha@clunet.edu
Abstract:
A critical review of recent developments in the use of chemometric experimental design based optimization techniques in capillary electrophoresis applications is presented. Current advances have led to enhanced separation capabilities of a wide range of analytes in such areas as biological, environmental, food technology, pharmaceutical, and medical analysis. Significant developments in design, detection methodology and applications from the last 5 years (2002-2007) are reported. Furthermore, future perspectives in the use of chemometric methodology in capillary electrophoresis are considered.
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