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Updated: Jul 10, 2026

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.
Published on: February 8, 2015
[Pathogenesis of breast cancer]
Ole William Petersen1, Julio E Celis
1Københavns Universitet, Institut for Cellulaer og Molekylaer Medicin, Panumbygningen, Det Sundhedsvidenskabelige Fakultet, København N. o.w.petersen@mai.ku.dk
Tumor heterogeneity, a cancer hallmark, may arise from rare cancer stem cells. These cells are crucial for understanding breast cancer evolution and developing new therapies.
Area of Science:
- Oncology
- Cell Biology
- Cancer Research
Background:
- Tumor heterogeneity is a key characteristic of cancer.
- Traditionally attributed to genomic instability and cellular evolution.
- Emerging evidence points to cancer stem cells as a significant contributor.
Purpose of the Study:
- To explore the existence and role of normal and cancer stem cells in the human breast.
- To investigate the potential involvement of these cells in breast cancer development and progression.
Main Methods:
- Review of current literature on cancer stem cells.
- Discussion of theoretical models for stem cell function in normal and malignant breast tissue.
Main Results:
- Cancer stem cells are proposed as a rare but critical population driving tumor growth.
- These cells may originate from normal stem cells or undergo transformation.
Conclusions:
- Cancer stem cells offer a new perspective on tumor heterogeneity and breast cancer evolution.
- Understanding cancer stem cells is vital for targeted therapies and improved patient outcomes.
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