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Updated: Jul 10, 2026
05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Design and evaluation of floating multi-layer coated tablets based on gas formation
Srisagul Sungthongjeen1, Pornsak Sriamornsak, Satit Puttipipatkhachorn
1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand. sungts2000@yahoo.com <sungts2000@yahoo.com>
Summary
New floating multi-layer tablets utilize gas formation for gastroretention. These promising drug delivery systems offer sustained release and good floating properties, enhancing drug delivery.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Gastroretentive drug delivery systems aim to prolong drug residence time in the stomach.
- Gas-forming floating tablets offer a promising approach for achieving gastroretention.
- Designing effective floating systems requires careful selection of coating materials and formulation components.
Purpose of the Study:
- To design and characterize novel multi-layer floating tablets for gastroretention.
- To investigate the influence of formulation variables on floating behavior and drug release kinetics.
- To evaluate the suitability of different polymeric membranes for gas entrapment in floating tablets.
Main Methods:
- Development of multi-layer tablets with a drug core, protective layer, gas-forming layer (sodium bicarbonate), and gas-entrapped membrane.
- Mechanical property characterization of acrylic polymers (Eudragit RL 30D, RS 30D, NE 30D) and ethylcellulose using puncture tests.
- Evaluation of floating properties (time to float) and in vitro drug release profiles.
- Investigation of formulation parameters including core preparation method, gas-forming agent amount, and coating level.
Main Results:
- Eudragit RL 30D was selected as the gas-entrapped membrane due to its flexibility and permeability.
- Tablets successfully floated due to carbon dioxide gas formation and entrapment.
- Direct-compressed cores resulted in faster floating and drug release compared to wet-granulated cores.
- Increased gas-forming agent enhanced drug release, while increased membrane coating prolonged floating time and slightly reduced release rate.
Conclusions:
- Multi-layer floating tablets incorporating gas formation and a polymeric membrane demonstrate effective gastroretention.
- Formulation optimization allows for control over floating characteristics and drug release profiles.
- These floating tablets represent a promising gastroretentive drug delivery system with potential for improved therapeutic outcomes.
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