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Updated: Jul 10, 2026

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy
Published on: December 20, 2021
Enhanced spectral shaping in steady-state free precession imaging
Tolga Cukur1, Neal K Bangerter, Dwight G Nishimura
1Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA. cukur@stanford.edu
A new weighted-combination steady-state free precession (WC-SSFP) method reduces banding artifacts and improves fat suppression in MRI. This technique enhances image quality by preserving contrast and offering adjustable fat suppression for better tissue visualization.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Biomedical Engineering
- Medical Physics
Background:
- Balanced steady-state free precession (SSFP) imaging suffers from off-resonance artifacts and bright fat signals.
- Existing methods for artifact reduction, such as complex-sum SSFP and sum-of-squares SSFP, have limitations in balancing banding reduction and SNR efficiency.
- Current fat suppression techniques can lead to imperfect suppression due to the shape of their stop-bands.
Purpose of the Study:
- To introduce a novel weighted-combination SSFP (WC-SSFP) method for improved SSFP imaging.
- To address the challenges of banding artifacts and fat signal suppression in SSFP sequences.
- To develop a flexible method that allows for adjustable banding reduction and fat suppression.
Main Methods:
- A new multiple-acquisition SSFP combination technique, WC-SSFP, was developed.
- The method utilizes multiple datasets with varying RF phase increments.
- WC-SSFP was evaluated for its ability to preserve SSFP contrast, reduce banding, and separate fat and water signals.
Main Results:
- WC-SSFP effectively reduces banding artifacts while maintaining high SNR efficiency, comparable to sum-of-squares SSFP.
- The method significantly improves fat suppression by enhancing the stop-band performance without compromising pass-band characteristics.
- WC-SSFP demonstrates robustness in the presence of resonant frequency variations, preventing fat signal interference.
Conclusions:
- WC-SSFP offers a superior solution for mitigating banding artifacts and suppressing fat signals in SSFP MRI.
- The technique provides robust performance and preserves image contrast, enhancing diagnostic utility.
- WC-SSFP introduces a tunable parameter for application-specific optimization of banding reduction and fat suppression.
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