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Updated: Jul 10, 2026

Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
Published on: September 22, 2017
Experimental study of the new blood pump for the heart-lung bypass machine
N Khodeli1, J Partsakhashvili, Z Chkhaidze
1Scientific-Educational-Training Centre of Experimental Surgery, Institute of Morphology, Tbilisi, Georgia.
Abstract:
The functioning of the rolling pump in the system of artificial blood circulation is associated with a number of complications. For avoiding these complications, virtually new perfusion system is developed, in which the functions of a blood reservoir and a pump are united in hermetic cardiotomy reservoirs. The technical aspects of connecting this system to experimental animals are described. In comparison with the traditional machines the system has minimal volume of filling and does not damage blood corpuscles. Constructive pumping system and entire perfusion system are quite simple and the control system allows achievement of hemodynamic characteristics maximally close to physiological ones. In addition, the system could be applied on both, large and small experimental animals.

