Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cold comfort pharm.

S M Fleetwood-Walker1, C W J Proudfoot, E M Garry

  • 1Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh, UK. s.m.fleetwood-walker@ed.ac.uk

Trends in Pharmacological Sciences
|November 13, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of lateral olfactory tract stimulation on Fos immunoreactivity in vasopressin neurones of the rat piriform cortex.

Journal of neuroendocrinology·2017
Same author

Transparency and Reproducibility of Observational Cohort Studies Using Large Healthcare Databases.

Clinical pharmacology and therapeutics·2015
Same author

Quantitative assessment of increased sensitivity of chronic laminitic horses to hoof tester evoked pain.

Equine veterinary journal·2010
Same author

Comparison of subjective scoring systems used to evaluate equine laminitis.

Veterinary journal (London, England : 1997)·2010
Same author

Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia.

Molecular and cellular neurosciences·2005
Same author

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.

Proceedings of the National Academy of Sciences of the United States of America·2003
Same journal

Targeting developmental reprogramming: hPSC insights for cancer interception.

Trends in pharmacological sciences·2026
Same journal

July 2026 issue first authors.

Trends in pharmacological sciences·2026
Same journal

Chronobiomaterials for circadian-aligned brain therapeutics.

Trends in pharmacological sciences·2026
Same journal

Biosensors for translatable GPCR bias.

Trends in pharmacological sciences·2026
Same journal

ECM stiffness and epigenetics in organ fibrosis.

Trends in pharmacological sciences·2026
Same journal

Which HTT transcript to lower?

Trends in pharmacological sciences·2026
See all related articles

Cooling the skin can cause pain or provide relief. The TRPM8 ion channel plays a dual role in cool sensation, cold pain, and pain relief, offering therapeutic potential.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Skin cooling's dual effect on pain is debated.
  • Transient Receptor Potential (TRP) channels are key to temperature sensation.
  • TRPM8 is activated by cooling sensory nerve cells.

Purpose of the Study:

  • Review the role of TRPM8 in cool sensation and pain.
  • Explore TRPM8's potential analgesic effects in chronic pain.
  • Discuss mechanisms behind TRPM8's complex function.

Main Methods:

  • Analysis of recent knockout mouse studies.
  • Review of scientific literature on TRP channels and pain.
  • Hypothetical mechanism discussion.

Main Results:

Related Experiment Videos

  • TRPM8 is implicated in cool sensation and cold pain.
  • TRPM8 exhibits analgesic gating control over noxious inputs in chronic pain.
  • TRPM8 presents a complex, dual role in pain modulation.

Conclusions:

  • TRPM8 has a composite profile in pain states.
  • Further research with selective agents is needed.
  • TRP channels offer potential therapeutic opportunities for pain management.