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Updated: Jul 10, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Pseudoglandular-type melanoma: a rare melanoma variant
Mordechai M Tarlow1, Alfred S Nemlick, Jerry Rothenberg
1Department of Medicine, New Jersey Medical School, Newark, NJ, USA.
Journal of Cutaneous Pathology
|November 17, 2007
Summary
This study details a rare melanoma variant with a unique glandular growth pattern. The tumor, composed entirely of atypical melanocytes, highlights unusual histologic features in melanoma diagnosis.
Area of Science:
- Dermatopathology
- Oncology
- Histology
Background:
- Melanoma is a significant skin cancer with diverse histologic presentations.
- Nodular melanoma is a common subtype, but rare variants present diagnostic challenges.
Observation:
- A 64-year-old male presented with a primary nodular melanoma.
- The tumor exhibited an unusual histologic pattern, exclusively composed of atypical melanocytes arranged in a glandular structure.
Findings:
- The atypical melanocytes were confirmed positive for S-100 protein.
- This represents the second reported case of melanoma with glandular histology and the first entirely composed of these features.
Implications:
- This case expands the understanding of melanoma's histologic spectrum.
- Recognizing this rare variant is crucial for accurate diagnosis and appropriate patient management.
- Further research into the molecular underpinnings of this melanoma variant may be warranted.
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