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Tight-binding inhibition of cathepsin S by cystatins
D Brömme1, R Rinne, H Kirschke
1Institute of Biochemistry, Faculty of Medicine, Martin-Luther University, Halle (Saale), Germany.
Biomedica Biochimica Acta
|January 1, 1991
Abstract:
Human cystatins A, B and C were purified, and their inhibition efficiency was tested with the cysteine proteinase cathepsin S. Cathepsin S was strongly inhibited by cystatins A and B in the subnanomolar range and by cystatin C in the picomolar range. Two steps of inhibition of cathepsin S by the cystatins which involve slow binding are discussed.