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Updated: Jul 10, 2026
11:11
Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment
Published on: January 24, 2020
Cytokine therapy for cancer
Seunghee Kim-Schulze1, Bret Taback, Howard L Kaufman
1The Tumor Immunology Laboratory, Division of Surgical Oncology, 622 West 168th Street, Columbia University, New York, NY 10032, USA.
Surgical Oncology Clinics of North America
|November 21, 2007
Summary
This review explores cytokine biology and their role in tumor immunotherapy, focusing on melanoma and renal cell carcinoma. New cytokine therapies offer promising directions for cancer treatment.
Area of Science:
- Immunology
- Oncology
- Pharmacology
Background:
- Cytokines are crucial signaling molecules in the immune system.
- Tumor immunotherapy aims to harness the immune system to fight cancer.
- Understanding cytokine biology is key to developing effective cancer treatments.
Purpose of the Study:
- To review the basic biology of major cytokines for tumor immunotherapy.
- To describe the clinical role of cytokine therapy in human tumors, specifically melanoma and renal cell carcinoma.
- To present new cytokines and suggest future research directions.
Main Methods:
- Literature review of basic cytokine biology.
- Analysis of clinical data on cytokine therapy for specific cancers.
- Exploration of emerging cytokines and combination therapies.
Main Results:
- Detailed overview of key cytokines relevant to cancer immunotherapy.
- Clinical efficacy and challenges of current cytokine therapies.
- Identification of novel cytokines and potential therapeutic strategies.
Conclusions:
- Cytokine therapy holds significant potential for treating human cancers.
- Further research into novel cytokines and combination approaches is warranted.
- Advances in understanding immunoregulation and the tumor microenvironment offer new therapeutic targets.
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