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Published on: May 24, 2017
Studies on DNA dynamics using 2-N-tert-butylaminoxylpurines
Mariko Aso1, John Walter Mirc, Manami Kurita
1Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Abstract:
2-N-tert-Butylaminoxylpurines (1) and (2) were synthesized from 2'-deoxy-6-chloropurine derivative by lithiation strategy. Effects of motion of 1 and 2 on EPR spectra were studied by EPR measurement in sucrose solution at various temperatures. The single stranded and duplexed 15-mers containing 1 showed the clear difference in the EPR spectra to indicate 1 has the potential to accurately study the dynamics of purine residues.
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