Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood analysis by Raman spectroscopy.

Annika M K Enejder, Tae-Woong Koo, Jeankun Oh

    Optics Letters
    |November 23, 2007
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care.

    Clinical chemistry·2026
    Same author

    [Applications of chatbots in undergraduate and postgraduate medical education: an emerging tool with transformative potential].

    Medicina·2026
    Same author

    Evaluating the Accuracy of Partial Least Square Regression for Distillation Fractions from ATR-IR Spectra of Crude Oils, with a Focus on Selected Crudes and Fractions.

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
    Same author

    Evaluation of a polarization-enhanced laparoscopy prototype for improved intra-operative visualization of peritoneal metastases.

    Scientific reports·2023
    Same author

    Tuberculosis treatment without rifampin in kidney/kidney-pancreas transplantation: A case series report.

    Transplant infectious disease : an official journal of the Transplantation Society·2022
    Same author

    Comparing the predictions by NIR spectroscopy based multivariate models for distillation fractions of crude oils by F-test.

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2022
    Same journal

    Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

    Optics letters·2026
    Same journal

    E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

    Optics letters·2026
    Same journal

    Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

    Optics letters·2026
    Same journal

    Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

    Optics letters·2026
    Same journal

    Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

    Optics letters·2026
    Same journal

    Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

    Optics letters·2026
    See all related articles

    Near-infrared Raman spectroscopy enables accurate, simultaneous measurement of multiple blood analytes without sample processing. This non-invasive technique shows feasibility for quantitative biomolecular analysis in complex biological samples.

    Area of Science:

    • Biomedical Optics
    • Analytical Chemistry
    • Spectroscopy

    Background:

    • Accurate quantification of blood analytes is crucial for clinical diagnostics.
    • Traditional methods often require sample processing, increasing time and cost.
    • Developing non-invasive techniques for real-time blood analysis remains a significant challenge.

    Purpose of the Study:

    • To investigate the feasibility of using near-infrared Raman spectroscopy for simultaneous, accurate quantification of multiple analytes in whole blood.
    • To assess the performance of a novel Raman spectroscopy instrument designed for turbid media.

    Main Methods:

    • Utilized near-infrared Raman spectroscopy with nonimaging optics for whole blood analysis.
    • Employed Monte Carlo simulations to optimize instrument design for light scattering and absorption by blood cells.

    Related Experiment Videos

  • Applied partial least-squares (PLS) analysis for quantitative predictions of analytes.

    • Main Results:

    • Simultaneously measured glucose, urea, total protein, albumin, triglycerides, hematocrit, and hemoglobin with clinical accuracy.
    • Achieved high precision in quantitative predictions, with r(2) values exceeding 0.93.
    • Confirmed that predictions were based on molecular information from Raman spectra.

    Conclusions:

    • Near-infrared Raman spectroscopy is a feasible method for non-invasive, quantitative analysis of multiple blood analytes.
    • The developed instrument and methodology overcome challenges associated with light scattering and absorption in whole blood.
    • This technology holds promise for rapid, point-of-care diagnostic applications.