[Determination of residual organic solvents in Panax notoginseng extracts by capillary gas chromatography with headspace sampling]
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Published on: June 9, 2021
Han-hua Wang1, Zhen-zhen Ni, Tong-wei Yao
1Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Objective:
To develop a headspace gas chromatography method for the determination of residual organic solvents in Panax notoginseng extracts.
Methods:
The samples were injected into HP-INNOWAX capillary column by headspace sampler and analyzed with FID detector using standard addition method.
Results:
There was a good linearity in the experimental concentration (r=0.9932-0.9999). The rate of recovery was in the rang of 81.74%-111.2%. The numbers of theoretical plates were more than 15000 and the resolutions between the adjacent peaks were more than 2. The RSD of precision and accuracy were both less than 10 %.
Conclusion:
The method is simple,accurate and sensitive with good reproducibility, which can be used for the determination of the residual organic solvents in Panax notoginseng extracts.
