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Published on: October 6, 2020
A mathematical model of pH(i) regulation in central CO2- chemoreception
Juan M Cordovez1, Chris Clausen, Leon C Moore
1State University of New York at Stony Brook, Department of Physiology and Biophysics, USA. jcordove@ic.sunysb.edu
Abstract:
In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH(i)) while in non-chemosensitive neurons pH(i) recovery is observed. The precise mechanisms for the differential regulation of pH(i) recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pH(i) regulation in central CO2 chemoreception.
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