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Updated: Jul 8, 2026
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Cell Tracking Using Photoconvertible Proteins During Zebrafish Development
Published on: September 28, 2012
Fluorescent proteins in zebrafish cell and developmental biology
1Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Methods in Cell Biology
|December 25, 2007
Summary
Zebrafish embryos offer powerful insights into cellular processes and disease development. Fluorescent proteins enable sophisticated genetic screens and modeling of cancers like leukemia.
Area of Science:
- Developmental Biology
- Genetics
- Molecular Biology
Background:
- Zebrafish embryos are valuable vertebrate models for studying cellular development and disease.
- Advances in fluorescent protein technology provide novel experimental strategies.
- Fluorescent proteins facilitate sophisticated genetic and chemical screens.
Purpose of the Study:
- To review key applications of fluorescent proteins in zebrafish research.
- To highlight their use in analyzing kinesin motor function, axonal guidance, and cancer models.
Main Methods:
- Utilizing fluorescent protein technology in zebrafish models.
- Employing forward genetic and chemical modifier screens.
- Developing transgenic zebrafish for disease modeling.
Main Results:
- Analysis of kinesin motor function in early zebrafish development.
- Determination of semaphorin roles in guiding nerve cell axons.
- Creation of transgenic zebrafish models for leukemia and other cancers.
Conclusions:
- Fluorescent proteins are instrumental in advancing zebrafish research.
- These applications enhance understanding of fundamental cellular processes and disease mechanisms.
- Zebrafish models with fluorescent proteins are crucial for future biological discoveries.
