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Updated: Jul 8, 2026

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
Published on: May 18, 2021
Targeted antibodies in dairy-based products
Lennart Hammarström1, Carina Krüger Weiner
1Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden. lennart.hammarstrom@ki.se
Bovine colostrum, rich in antibodies, offers crucial immune protection for calves. Immunizing cows boosts antibody levels, enhancing the efficacy of colostrum-derived products for preventing and treating human infectious diseases.
Area of Science:
- Veterinary Immunology
- Microbiology
- Human Health
Background:
- Bovine colostrum provides passive immunity to newborn calves via immunoglobulins.
- Antibody concentrations in colostrum can be increased through maternal immunization.
- Colostrum-derived immune milk shows promise in preventing and treating human infectious diseases.
Purpose of the Study:
- To highlight the role of bovine colostrum in providing passive immunity.
- To discuss methods for enhancing antibody levels in bovine colostrum.
- To review the therapeutic potential of bovine colostrum-based products in human medicine.
Main Methods:
- Review of existing literature on bovine colostrum and immunoglobulins.
- Analysis of immunization strategies to increase antibody titers in cows.
- Evaluation of clinical evidence for immune milk products in human disease prophylaxis and treatment.
Main Results:
- Bovine colostrum contains essential immunoglobulins for calf protection.
- Maternal immunization effectively elevates specific antibody concentrations in colostrum.
- Immune milk products demonstrate efficacy against human diarrheal diseases caused by pathogens like E. coli and rotavirus.
Conclusions:
- Bovine colostrum is a valuable source of passive immunity.
- Enhanced antibody levels through immunization improve colostrum's protective potential.
- Further research is needed to optimize antibody yield and concentration for complete protection.
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