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Predictive factors of early mortality in children with developmental disabilities: a case-comparison analysis

Ayala Cohen1, Eyal Asor, Emanuel Tirosh

  • 1Faculty of Industrial Engineering and Management Technion, Israel.

Journal of Child Neurology
|January 11, 2008
PubMed

Insights

Children with neurodevelopmental disabilities face early mortality risks from limited mobility, genetic factors, and hearing deficits. Comprehensive treatment at a child development center offers protection against these risks.

Area of Science:

  • Pediatrics
  • Developmental Pediatrics
  • Public Health

Background:

  • Neurodevelopmental disabilities (NDDs) present complex challenges for affected children and their families.
  • Understanding factors influencing early mortality in this population is crucial for improving care and outcomes.
  • Previous research has explored various risk factors, but a comprehensive analysis is needed.

Purpose of the Study:

  • To identify significant risk factors associated with early mortality in children with NDDs.
  • To compare risk factors between different control groups (age-matched and developmentally matched).
  • To evaluate the protective effect of comprehensive treatment at a child development center.

Main Methods:

  • Retrospective cohort study of 1000 children referred to a child development center (1975-1985).
  • Analysis of mortality data for 81 deceased children compared to age-matched and developmentally matched control groups.
  • Multivariate analysis to determine significant risk and protective factors.

Main Results:

  • Low developmental quotient, restricted mobility, assisted feeding, and genetic etiology were risk factors for early mortality compared to age-matched controls.
  • Restricted mobility, genetic etiology, and hearing deficit were significant risk factors compared to developmentally matched controls.
  • Comprehensive treatment at the child development center was a significant protective factor against early mortality.

Conclusions:

  • Key risk factors for early mortality in children with NDDs include mobility and feeding impairments, genetic etiology, and hearing deficits.
  • Socioeconomic variables were not found to be significant predictors of increased mortality risk.
  • Early and comprehensive intervention programs at specialized centers can significantly reduce mortality risk.

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