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The state of proteome profiling in the fungal genus Aspergillus

Yonghyun Kim1, M P Nandakumar, Mark R Marten

  • 1Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA.

Briefings in Functional Genomics & Proteomics
|January 12, 2008
PubMed

Insights

This review summarizes proteomic data for Aspergillus fungi, identifying 28 cell surface, 102 secreted, and 139 intracellular proteins. This fungal proteome map aids in understanding Aspergillus as a cellular factory for industry.

Area of Science:

  • Fungal biology
  • Proteomics
  • Industrial microbiology

Background:

  • The Aspergillus genus comprises filamentous fungi vital to a multibillion dollar industry.
  • Recent completion of fungal genome sequencing necessitates proteomic profiling for industrial applications.
  • Understanding the fungal cell factory is crucial for optimizing industrial processes.

Purpose of the Study:

  • To review and consolidate proteomic data for the Aspergillus genus.
  • To create a comprehensive proteome map of Aspergillus species.
  • To identify proteins within major metabolic pathways for biotechnological insights.

Main Methods:

  • Systematic review of published proteomic studies on Aspergillus.
  • Data extraction and categorization of identified proteins (cell surface, secreted, intracellular).
  • Compilation of proteomic data from 10 distinct Aspergillus research studies.

Main Results:

  • A total of 28 cell surface proteins have been identified.
  • 102 secreted proteins have been characterized.
  • 139 intracellular proteins were cataloged across the studies.

Conclusions:

  • The compiled proteomic data provides a foundational understanding of the Aspergillus proteome.
  • The presented proteome map highlights key proteins in major metabolic pathways.
  • This knowledge is essential for advancing Aspergillus in industrial biotechnology and cell factory applications.

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