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13:47
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
Published on: May 19, 2020
Current status of group A streptococcal vaccine development
1University of Tennessee Health Science Center, Memphis 38104, USA. James.dale@va.gov
Advances in Experimental Medicine and Biology
|January 16, 2008
Summary
Developing vaccines against Group A Streptococcus (GAS) infections shows promise. Surface M protein-based vaccines are advancing, with a 26-valent candidate nearing pediatric trials for global health impact.
Area of Science:
- Microbiology
- Immunology
- Vaccinology
Background:
- Detailed understanding of Group A Streptococcus (GAS) molecular pathogenesis.
- Identification of vaccine candidates based on molecular discoveries.
Purpose of the Study:
- To develop and evaluate novel vaccines for GAS infections.
- To prevent GAS-related sequelae such as acute rheumatic fever (ARF) and rheumatic heart disease (RHD).
Main Methods:
- Utilizing molecular techniques to engineer multivalent M protein-based vaccines.
- Assessing vaccine candidates for protection in animal models.
- Evaluating immunogenicity and safety in human volunteers.
Main Results:
- Surface M protein identified as a leading protective antigen.
- M antibodies correlate with protection against GAS infection.
- A 26-valent M protein vaccine is well-tolerated and immunogenic in adults.
Conclusions:
- Advanced M protein-based vaccines are in development, free from cross-reactive epitopes.
- A 26-valent vaccine shows potential for pediatric trials.
- Vaccine deployment could significantly impact global health by preventing GAS infections and complications.
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