[Vimentin-immunopositive cells in the rat telencephalon after experimental ischemic stroke]

The aim of the study was to detect the cells synthesizing intermediate filament protein vimentin in the telencephalon of intact rats and animals exposed to unilateral permanent occlusion of middle cerebral artery accepted as a model of ischemic stroke. In intact rat telencephalon, vimentin-positive cells were detected within the cerebral barriers. 14 days following the occlusion of middle cerebral artery, numerous vimentin-positive cells appeared in the perifocal zone of the lesion (penumbra) making up a majority of cells of the regenerating nervous tissue at the border with intact brain tissue. In the subependimal proliferative zone, a large number of small, vimentin-negative cells was observed that were located among the long processes of vimentin-positive cells directed towards the lesion area. The data obtained demonstrate predominant localization of vimentin-immunopositive cells of (in both intact and lesioned brain) in the zone of barrier structures' formation.