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Updated: Jul 8, 2026

Mouse Models of Periventricular Leukomalacia
Published on: May 18, 2010
[Periventricular leukomalacia and spastic diplegia: implications in the psycholinguistic abilities]
Dionísia Aparecida Cusin Lamônica1, Plínio Marcos Duarte Pinto Ferraz
1Departamento de Fonoaudiologia, Faculdade de Odontologia de Bauru, Universidade de São Paulo, São Paulo. dionelam@uol.com.br
Insights
Children with spastic diplegic cerebral palsy (D-CP) and periventricular leukomalacia (PVL) show psycholinguistic deficits. Motor impairment significantly impacts their language and cognitive skills.
Area of Science:
- Neuroscience
- Developmental Psychology
- Pediatrics
Context:
- Spastic diplegic cerebral palsy (D-CP) is often linked to periventricular leukomalacia (PVL).
- PVL impacts motor, visual, auditory, and somatosensory pathways.
- Understanding psycholinguistic skills in D-CP is crucial for early intervention.
Purpose:
- To assess psycholinguistic abilities in children with D-CP and PVL.
- To investigate correlations between cognitive performance, motor impairment, and psycholinguistic skills.
- To compare auditory and visual processing in affected children.
Summary:
- Eight children (4-6 years) with D-CP and PVL were evaluated using the ITPA and PPVT.
- Significant correlations found between cognitive performance, PPVT, and auditory reception (ITPA).
- Children performed better in visual than auditory tasks, with motor impairment affecting psycholinguistic outcomes.
Impact:
- Children with D-CP and PVL exhibit psycholinguistic deficits.
- Motor impairment is a significant factor influencing psycholinguistic development.
- Highlights the need for further research into psycholinguistic development in this population.
Background:
spastic diplegic cerebral palsy (D-CP) is frequently related to periventricular leukomalacia (PVL), which usually affects the descending motor fibers of the association cortex and association fibers of the visual, auditory and somesthesic functions.
Aim:
to verify the performance of children with D-CP regarding their psycholinguistic skills.
Method:
participants were eight individuals of both genders and with chronological ages varying from four to six years, diagnosed with D-CP, having PVL confirmed through magnetic resonance. These children were evaluated through the Illinois Test of Psycholinguistic Abilities (ITPA) and the Peabody Picture Vocabulary Test (PPVT), considering the cognitive performance, the level of motor impairment and the performance in the auditory and visual subtests of the ITPA.
Results:
the results pointed to a significant correlation between the cognitive performance and the PPVT. The same correlation was confirmed between the PPVT and the subtest of auditory reception of the ITPA, when considering the psycholinguistic age. In the comparison between the auditory and visual abilities, the participants demonstrated a better performance in the activities that involved visual abilities, indicating a significant correlation in the association subtest. There was a statistically significant correlation between the level of motor impairment and the psycholinguistic performance, confirming the influence of the motor impairment in these activities.
Conclusion:
the children with D-CP and with suggestive signs of PVL presented deficits in the psycholinguistics abilities, justifying the need of additional studies in this area in order to investigate the development of these abilities.
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