[Lipid peroxidation in dog lung microsomes]

The changes in lipid composition of dog lung microsomes during Fe3+/NADPH-induced peroxidation and correlation between malondialdehyde production and polyunsaturated fatty acids consumption were investigated. It was shown, that microsomal peroxidation causes phosphatidylcholine and phosphatidylethanolamine content decrease, with concomitant increase in lysophosphoglyceride content. Malondialdehyde production intensity was correlated with arachidonic and docosahexaenoic acid consumption. The changes thus observed, may be engaged in pathogenesis of respiratory distress syndrome.