Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral nerve regeneration.

F J Liuzzi1, B Tedeschi

  • 1Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk.

Neurosurgery Clinics of North America
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokeratin and Desmoplakin Analogues within an Intracellular Parasite.

The Biological bulletin·2018
Same author

[Cancer screening programme in health care workers].

Giornale italiano di medicina del lavoro ed ergonomia·2011
Same author

Short-term estrogen replacement increases beta-preprotachykinin mRNA levels in uninjured dorsal root ganglion neurons, but not in axotomized neurons.

Experimental neurology·2001
Same author

Antigen processing of vesicular stomatitis virus in situ. Interdigitating dendritic cells present viral antigens independent of marginal dendritic cells but fail to prime CD4(+) and CD8(+) T cells.

Immunology·2000
Same author

Effects of testosterone on a cross-facial nerve graft model.

Journal of reconstructive microsurgery·2000
Same author

Three subpopulations of fast axonally transported retinal ganglion cell proteins are differentially trafficked in the rat optic pathway.

Journal of neuroscience research·2000
Same journal

Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Spinal Cord Deformities Associated with Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Radiation Therapy for Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Treatment Strategies of Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Vascular Lesions of the Spinal Cord: Arteriovenous and Cavernous Malformations.

Neurosurgery clinics of North America·2026
Same journal

Hemangioblastomas of the Spinal Cord.

Neurosurgery clinics of North America·2026
See all related articles

Peripheral nerve regeneration relies on neuron survival, axonal growth, and specific reinnervation. While neurotrophic factors like NGF aid survival and Schwann cells support outgrowth, precise target reinnervation remains a challenge.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Peripheral Nervous System Biology

Background:

  • Peripheral nerve injury leads to significant loss of axotomized neurons, including primary sensory (DRG) and motoneurons.
  • Neuron survival post-axotomy can depend on neurotrophic factors, such as nerve growth factor (NGF), and potentially gonadal hormones.
  • Axonal regeneration requires extracellular matrix molecules for adhesion and non-neuronal cells, like Schwann cells, which produce growth factors.

Purpose of the Study:

  • To investigate the critical factors influencing peripheral nerve regeneration success.
  • To understand the roles of neuron survival, axonal outgrowth, and reinnervation specificity.
  • To explore mechanisms guiding regenerating axons to their correct targets.

Main Methods:

Related Experiment Videos

  • Review of experimental evidence on peripheral nerve injury and regeneration.
  • Analysis of neurotrophic factor effects (e.g., NGF) on neuron survival.
  • Examination of cellular and molecular mechanisms supporting axonal elongation and target reinnervation.

    • Main Results:

    • Nerve growth factor (NGF) can significantly improve the survival of axotomized DRG neurons.
    • Schwann cells and extracellular matrix components like laminin are crucial for axonal elongation.
    • While neurotrophic factors and physical guidance cues both play roles in reinnervation specificity, physical constraints can override tropic factors, leading to aberrant reinnervation.

    Conclusions:

    • Peripheral nerve regeneration success hinges on neuronal survival, axonal outgrowth, and precise target reinnervation.
    • Aberrant reinnervation and misrouting frequently occur, causing functional deficits.
    • Further research is needed to harness developmental mechanisms for improving nerve regeneration specificity in clinical settings.