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Updated: Jul 8, 2026
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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Early bone tissue responses to turned and oxidized implants in the rabbit tibia
Patricia Miranda Burgos1, Lars Rasmusson, Luiz Meirelles
1Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. Patricia.miranda-burgos@biomaterials.gu.se
Clinical Implant Dentistry and Related Research
|January 26, 2008
Summary
Titanium implant surface modifications, specifically anodic oxidation, enhance early bone integration through direct bone formation. This contrasts with turned surfaces, which integrate via bone ingrowth, offering insights into osseointegration mechanisms.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Implantology
Background:
- Anodic oxidation creates moderately rough, porous titanium surfaces.
- Oxidized titanium surfaces show increased bone contacts compared to turned surfaces.
- Mechanisms of enhanced bone response to oxidized titanium require further elucidation.
Purpose of the Study:
- To investigate and describe the early stages of bone integration for titanium implants.
- To compare the osseointegration processes of oxidized and turned titanium surfaces.
Main Methods:
- Utilized New Zealand White rabbits (n=9) with 18 threaded titanium implants.
- Compared one oxidized and one turned implant placed in the tibial metaphysis.
- Analyzed implants retrieved at 7, 14, and 28 days using light microscopy and histomorphometry.
Main Results:
- Oxidized implants demonstrated direct bone formation on the surface.
- Turned implants integrated through bone ingrowth from surrounding tissues.
- Oxidized implants showed higher bone contact, while turned implants had higher bone area.
Conclusions:
- Implant surface modification significantly influences bone tissue response.
- Early bone formation on oxidized surfaces occurs directly.
- Turned surfaces integrate via ingrowth from adjacent bone and bone marrow.
