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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
[Advances in the studies of miRNAs and cell apoptosis]
1Southern Medical University, Department of Radiation Medicine, Guangzhou 510515, China.
Abstract:
MicroRNAs (miRNAs) are a recently discovered class of 18 - 24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16.
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