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Related Experiment Videos

Epithelial topology.

Radhika Nagpal1, Ankit Patel, Matthew C Gibson

  • 1School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|February 23, 2008
PubMed
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Biological order can emerge from physical principles, not just genetics. Our model shows stochastic cell division in epithelial sheets creates a conserved, non-Gaussian cell shape distribution across species.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biophysics

Background:

  • Genetic control is the primary principle in development and homeostasis.
  • Emergent biological order can arise from physical principles and self-organization, independent of direct genetic instruction.
  • Analysis of these emergent processes is challenging due to their interdisciplinary nature.

Purpose of the Study:

  • To review literature on topological order in proliferating epithelia.
  • To explore new ideas on the origins and implications of emergent cellular order.
  • To discuss a mathematical model predicting cell shape distribution.

Main Methods:

  • Literature review of topological models in cellular morphogenesis.
  • Exploration of mathematical and physical principles governing biological order.

Related Experiment Videos

  • Analysis of stochastic processes in cell division.

    • Main Results:

    • A mathematical model predicts a non-Gaussian distribution of polygonal cell shapes in epithelial sheets.
    • This specific cell shape distribution arises from stochastic cell division.
    • The observed cell shape distribution is conserved across diverse animals and plants.

    Conclusions:

    • Emergent topological order plays a significant role in cellular morphogenesis.
    • Physical principles and stochastic processes contribute to biological order beyond genetic control.
    • Understanding these emergent properties is crucial for cell and developmental biology.