Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polarization-interferometric surface-plasmon-resonance imaging system.

Ju-Yi Lee1, Teng-Ko Chou, Hsueh-Ching Shih

  • 1Institute of Opto-Mechatronics Engineering and Department of Mechanical Engineering, National Central University, Chung-Li, Taiwan. juyilee@cc.ncu.edu.tw

Optics Letters
|March 4, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic range enhancement of the roll angle displacement measurement with birefringence using a polarization camera.

Applied optics·2021
Same author

Measurement of the refractive index of lenses from the maximum phase difference of the total internal reflection with a polarization camera.

Applied optics·2021
Same author

Standing-wave interferometer based on single-layer SiO<sub>2</sub> nano-sphere scattering.

Optics express·2017
Same author

Development of an angular displacement measurement technique through birefringence heterodyne interferometry.

Optics express·2016
Same author

Displacement measurement using a wavelength-phase-shifting grating interferometer.

Optics express·2013
Same author

Heterodyne common-path grating interferometer with Littrow configuration.

Optics express·2013
Same journal

Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

Optics letters·2026
Same journal

E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

Optics letters·2026
Same journal

Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

Optics letters·2026
Same journal

Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

Optics letters·2026
Same journal

Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

Optics letters·2026
Same journal

Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

Optics letters·2026
See all related articles

This study introduces a novel 2D phase-detection system for surface-plasmon-resonance (SPR) sensors, achieving high sensitivity for biomolecular interaction detection with excellent phase stability.

Area of Science:

  • Optics and Photonics
  • Biomedical Sensing
  • Surface Plasmon Resonance (SPR) Technology

Background:

  • Surface-plasmon-resonance (SPR) sensors are crucial for label-free biomolecular interaction analysis.
  • Traditional SPR systems face challenges in sensitivity, stability, and real-time array detection capabilities.
  • Accurate phase detection is essential for enhancing SPR sensor performance.

Purpose of the Study:

  • To develop and demonstrate a two-dimensional (2D) phase-detection system for SPR sensors.
  • To improve the sensitivity and stability of SPR-based biomolecular detection.
  • To enable real-time array detection for high-throughput analysis.

Main Methods:

  • Utilized polarization interferometry to detect phase differences between s and p polarizations.

Related Experiment Videos

  • Implemented a common-optical-path configuration to minimize ambient disturbances.
  • Developed a 2D phase-detection system for spatial variation analysis.

    • Main Results:

    • Successfully detected spatial phase-difference variations (< 1 x 1 mm^2) from biomolecular interactions.
    • Achieved a phase stability of approximately 0.09 degrees.
    • Demonstrated a refractive index detection limit of approximately 4.3 x 10^-6.
    • Confirmed the capability for real-time array detection.

    Conclusions:

    • The proposed 2D phase-detection system significantly enhances SPR sensor performance.
    • The system offers high sensitivity, stability, and real-time array detection capabilities.
    • This advancement holds promise for label-free, high-throughput biomolecular analysis.