Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current Status of the Diagnosis and Treatment of Mismatch Repair Deficient Colorectal Cancer.

Biomedicines·2026
Same author

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2025.

Current oncology (Toronto, Ont.)·2026
Same author

Molecular lineages of sporadic mismatch-repair deficient colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Corrigendum to "A non-randomized phase 2 trial of pembrolizumab in untreated patients with carcinoma of unknown primary site" [Eur J Cancer (2026) 239 116709].

European journal of cancer (Oxford, England : 1990)·2026
Same author

A non-randomized phase 2 trial of pembrolizumab in untreated patients with carcinoma of unknown primary site.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Sensitivity of metastatic mucinous tailgut cyst adenocarcinoma to gemcitabine and radiation: a case report.

Frontiers in oncology·2026

Related Experiment Video

Updated: Jul 7, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Systemic therapy for colon cancer.

Timothy R Asmis1, Leonard Saltz

  • 1Gastrointestinal Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Gastroenterology Clinics of North America
|March 4, 2008
PubMed
Summary

Colorectal cancer (CRC) treatment has advanced significantly. This review covers chemotherapy and targeted therapy options for CRC patients, detailing their effectiveness and side effects.

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a prevalent and often lethal malignancy in North America.
  • Effective CRC management necessitates a comprehensive, multidisciplinary strategy encompassing prevention, diagnosis, and treatment.

Purpose of the Study:

  • To review current chemotherapy and targeted therapy options for colorectal cancer.
  • To analyze the indications, efficacy, and toxicity profiles of these advanced CRC treatments.

Main Methods:

  • Literature review of recent advancements in CRC treatment.
  • Synthesis of data on chemotherapy and targeted therapy regimens.
  • Analysis of clinical trial outcomes and toxicity data.

Main Results:

  • Significant progress in surgical and medical CRC treatments over the past decade.

More Related Videos

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model
07:03

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

Related Experiment Videos

Last Updated: Jul 7, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model
07:03

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

  • Established indications and efficacy for various chemotherapy agents.
  • Identified key targeted therapies and their specific roles in CRC management.
  • Documented common toxicities associated with CRC treatments.

    • Conclusions:

    • Chemotherapy and targeted therapy are integral components of modern CRC treatment.
    • Understanding treatment efficacy and toxicity is crucial for optimizing patient outcomes.
    • Continued research is vital for further improving CRC survival rates and quality of life.