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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
The link between IL-23 and Th17 cell-mediated immune pathologies.
Mandy J McGeachy1, Daniel J Cua
1Schering-Plough Biopharma (Formerly DNAX Research), 901 California Avenue, Palo Alto, CA 94304, United States. mandy.mcgeachy@spcorp.com
Seminars in Immunology
|March 6, 2008
Summary
Interleukin-23 (IL-23) and T helper 17 (Th17) cells are key in autoimmune inflammation. This review explores Th17 cell discovery, regulation, and the complex roles of IL-23 in disease.
Area of Science:
- Immunology
- Cell Biology
- Inflammation Research
Background:
- Interleukin-23 (IL-23) and T helper 17 (Th17) cells are implicated in autoimmune inflammation.
- The precise relationship between IL-23 and Th17 cells in disease pathogenesis is debated.
Purpose of the Study:
- To review the discovery and characterization of Th17 cells.
- To elucidate the regulatory mechanisms governing Th17 cells.
- To discuss the role of IL-23 in inflammatory diseases concerning Th17 cell function.
Main Methods:
- Literature review of immunological studies.
- Analysis of T helper cell subsets.
- Examination of cytokine signaling pathways.
Main Results:
- Th17 cells represent a distinct T helper subset.
- IL-23 plays a significant role in Th17 cell development and function.
- Dysregulation of IL-23/Th17 axis contributes to autoimmune diseases.
Conclusions:
- Understanding the IL-23 and Th17 cell interplay is crucial for autoimmune disease research.
- Targeting the IL-23/Th17 pathway offers potential therapeutic strategies.
- Further research is needed to fully delineate their complex interactions.
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