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Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Oral Drug Delivery Systems: Introduction

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

Drug Delivery Systems: Different Types

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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Updated: Jul 6, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Published on: August 16, 2010

Drug delivery systems - an overview.

Kewal K Jain¹

¹Jain PharmaBiotech, Basel, Switzerland.

Methods in Molecular Biology (Clifton, N.J.)

|March 29, 2008

Summary

This summary is machine-generated.

This overview covers drug delivery systems (DDS), highlighting nanoparticles and personalized medicine advancements. It discusses challenges and future prospects for optimizing drug administration and therapeutic outcomes.

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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

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Last Updated: Jul 6, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Published on: August 16, 2010

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Area of Science:

Pharmaceutical Sciences
Biotechnology
Nanotechnology

Background:

Drug delivery systems (DDS) are crucial for effective therapeutic outcomes.
Optimizing drug administration routes, formulations, and devices remains a key challenge.
The delivery of biologics like proteins and peptides requires specialized approaches.

Purpose of the Study:

To provide a comprehensive overview of current drug delivery systems.
To explore the role of nanoparticles in advancing drug delivery.
To discuss the implications of refined DDS for personalized medicine.

Main Methods:

Literature review of drug administration routes.
Analysis of various drug formulations and delivery devices.
Examination of nanoparticle-based drug delivery strategies.
Discussion of personalized medicine components (pharmacogenomics, pharmacogenetics, pharmacoproteomics).

Main Results:

Nanoparticles offer significant potential for refining both pharmaceutical and diagnostic drug delivery.
Advancements in DDS are pivotal for the progression of personalized medicine.
The study outlines the ideal characteristics of DDS, commercial considerations, and current achievements.

Conclusions:

Refined drug delivery systems, particularly those utilizing nanoparticles, are essential for personalized medicine.
Addressing challenges in DDS development is critical for future therapeutic innovations.
The field is poised for significant advancements, impacting patient care and treatment efficacy.