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Related Experiment Videos

Electrospray-ionization driven by dielectric polarization.

Michael Schilling1, Dirk Janasek, Joachim Franzke

  • 1ISAS - Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, 44139, Dortmund, Germany. schilling@isas.de

Analytical and Bioanalytical Chemistry
|April 1, 2008
PubMed
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A novel electrospray ionization method using a non-conductive piezo ceramic plate reduces discharge risks for mass spectrometry. This technique shows applicability for determining compounds like reserpine and myoglobin.

Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Electrospray ionization (ESI) is a crucial technique in mass spectrometry.
  • Traditional ESI methods can be susceptible to electrical discharges, potentially affecting analysis.
  • Developing safer and more robust ionization methods is essential for sensitive detection.

Purpose of the Study:

  • To introduce and evaluate a novel electrospray ionization method utilizing a non-conductive piezo ceramic plate.
  • To demonstrate the reduction of electrical discharge risks associated with high electric currents.
  • To compare the performance of this new method with a commercial electrospray system.

Main Methods:

  • A non-conductive piezo ceramic plate was employed to generate an electric field for electrospray.
  • The generated electrospray was used as an ionization method for mass spectrometric determination.

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  • The technique's applicability was tested using reserpine and myoglobin as analytes.

    • Main Results:

    • The non-conductive piezo ceramic plate successfully induced an electric field to generate an electrospray.
    • The method demonstrated a decreased risk of undesired discharges compared to conventional high-current methods.
    • Successful mass spectrometric determination of reserpine and myoglobin was achieved, comparable to a commercial ESI system.

    Conclusions:

    • The piezo ceramic plate electrospray ionization is a viable and safer alternative for mass spectrometry.
    • This technique offers improved stability and reduced risk of electrical interference.
    • The method is applicable for the analysis of various compounds, including small molecules and proteins.