Preparation of nonsymmetrically substituted stilbenes in a one-pot two-step heck strategy using ethene as a reagent
Chad M Kormos1, Nicholas E Leadbeater
1Department of Chemistry, University of Connecticut, Storrs, CT 06269-3060, USA.
Abstract:
We present here a strategy for the preparation of nonsymmetrically substituted stilbenes using a one-pot two-step double Heck strategy. First a protocol is developed for the selective preparation of a range of styrenes using ethene as the alkene coupling partner. Then conditions are found for the effective coupling of the styrenes with aryl halides using a 1:1 stoichiometric ratio of the two components. The use of the microwave apparatus to perform the reactions offers a convenient method for synthesis as well as for safely, easily, and accurately loading vessels with gaseous reagents.
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