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Related Experiment Videos

Growth hormone-binding proteins.

G Baumann1

  • 1Center for Endocrinology, Metabolism and Nutrition, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.

Trends in Endocrinology and Metabolism: TEM
|September 1, 1990
PubMed
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Human plasma contains two growth hormone-binding proteins (GH-BPs) that regulate growth hormone levels. Deficiencies in high-affinity GH-BP are linked to growth disorders, highlighting their crucial role.

Area of Science:

  • Endocrinology
  • Protein Chemistry

Background:

  • Human plasma contains two distinct growth hormone-binding proteins (GH-BPs) with varying affinities.
  • A high-affinity GH-BP is identified as the extracellular domain of the growth hormone receptor.
  • A separate low-affinity GH-BP, unrelated to the receptor, has also been discovered.

Purpose of the Study:

  • To characterize the two identified human growth hormone-binding proteins (GH-BPs).
  • To investigate the physiological roles and implications of GH-BP levels in human plasma.

Main Methods:

  • Characterization of high and low affinity binding proteins for human growth hormone.
  • Analysis of GH-BP levels in plasma across different life stages.
  • Correlation of GH-BP levels with specific growth disorders.

Related Experiment Videos

Main Results:

  • Approximately 45% of plasma GH is bound by the high-affinity GH-BP, and 5% by the low-affinity GH-BP.
  • Plasma GH-BP levels increase from infancy to adulthood and remain stable.
  • Absent or reduced high-affinity GH-BP levels are observed in GH-resistant short stature conditions like Laron dwarfism.

Conclusions:

  • GH-BPs play a critical role in modulating growth hormone bioavailability and stability.
  • The high-affinity GH-BP is essential for normal growth, and its deficiency leads to GH resistance.
  • GH-BPs act as a reservoir and buffer system for circulating growth hormone.