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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
Published on: September 16, 2019
Skeletal muscle as an immunogenic organ
Søren Nielsen1, Bente Klarlund Pedersen
1The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Abstract:
During the past few years, a possible link between skeletal muscle contractile activity and immune changes has been established. This concept is based on the finding that exercise provokes an increase in a number of cytokines. We have suggested that cytokines and other peptides that are produced; expressed and released by muscle fibers and exert either paracrine or endocrine effects should be classified as 'myokines'. Human skeletal muscle has the capacity to express several myokines belonging to distinct different cytokine classes and contractile activity plays a role in regulating the expression of cytokines in skeletal muscle. In the present review, we focus on the myokines interleukin (IL)-6, IL-8 and IL-15 and their possible anti-inflammatory, immunoregulatory and metabolic roles.
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