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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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Related Experiment Video

Updated: Jul 5, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Using the Ensembl genome server to browse genomic sequence data.

Xosé M Fernández-Suárez1, Michael K Schuster

  • 1European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom.

Current Protocols in Bioinformatics
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

The Ensembl genome browser offers extensive human genome annotation and comparative genomic data. It helps researchers find genes, proteins, and related information for biomedical research.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Comparative genomics

Background:

  • The Ensembl genome browser is a key resource for accessing and interpreting genomic data.
  • Accurate gene annotation is crucial for understanding genome function and evolution.

Purpose of the Study:

  • To provide a guide on utilizing the Ensembl genome browser effectively.
  • To demonstrate how to access gene and protein information and external links.
  • To explain the use of comparative genomic data within the Ensembl platform.

Main Methods:

  • Web-based browser interface (Ensembl.org).
  • Integration of automatic genome annotation with external data sources.
  • Tools for searching and retrieving gene and protein information.
  • Comparative genomics visualization and analysis features.

Main Results:

  • Ensembl provides comprehensive, automatically annotated human genome sequences.
  • Confirmed gene predictions are integrated with diverse external datasets.
  • The browser facilitates efficient retrieval of specific gene/protein data and links.
  • Comparative genomic data is readily accessible for cross-species analysis.

Conclusions:

  • The Ensembl genome browser is an invaluable tool for researchers in genomics and related fields.
  • Its integrated data and user-friendly interface support various research applications.
  • Effective use of Ensembl enhances the exploration of genomic information and comparative studies.