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The type III secretion system tip complex and translocon.

C A Mueller1, P Broz, G R Cornelis

  • 1Biozentrum der Universität Basel, Basel, Switzerland.

Molecular Microbiology
|April 24, 2008
PubMed
Summary
This summary is machine-generated.

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Gram-negative bacteria use the injectisome to secrete proteins into host cells. A hydrophilic protein forms a tip complex on the needle, aiding the assembly of hydrophobic translocators into the host membrane.

Area of Science:

  • Microbiology
  • Cell Biology
  • Bacterial Pathogenesis

Background:

  • Gram-negative bacteria possess a type III secretion system (TSS), also known as the injectisome or needle complex.
  • The injectisome spans bacterial membranes and periplasm, with an external needle for protein translocation into host cells.

Purpose of the Study:

  • To elucidate the roles of translocator proteins in forming a translocation pore (translocon) within the host cell membrane.
  • To investigate the interaction between translocators, the injectisome needle, and translocon assembly.

Main Methods:

  • The abstract does not specify methods, but implies experimental investigation of protein interactions and assembly processes.

Main Results:

  • Two hydrophobic translocator proteins insert into the host cell membrane.

Related Experiment Videos

  • A third, hydrophilic translocator unexpectedly forms a tip complex on the injectisome needle.

    • Conclusions:

    • The hydrophilic translocator acts as an assembly platform for the hydrophobic translocators at the needle tip.
    • This mechanism facilitates the efficient formation of the translocon for bacterial protein delivery.