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Updated: Jul 5, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
[Epstein-Barr virus-associated large B-cell lymphoma in a patient with colitis ulcerosa treated with azathioprine]
Kristian Kofoed1, Marianne Kiszka-Kanowitz, Jens Mørch Albrectsen
1Hvidovre Hospital, Klinisk Forskningsenhed 136, Infektionsmedicinsk Afdeling, Hvidovre. kristian.kofoed@hvh.regionh.dk
Abstract:
A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV-associated large B-cell lymphoma was confirmed, he died from multiple organ failure. AZA and 6-mercaptopurine are associated with the development of EBV-positive lymphomas in organ-transplanted patients. This type of lymphoma is a rare complication in inflammatory bowel disease.
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