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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Nephrotic Syndrome I : Introduction

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Renal Corpuscle01:20

Renal Corpuscle

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Glomerulus: Structure and Function
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Diabetic Nephropathy01:28

Diabetic Nephropathy

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Updated: Jul 5, 2026

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Systemic diseases with renal manifestations.

Asha Rajashekar1, Mark A Perazella, Susan Crowley

  • 1Division of Nephrology, Yale School of Medicine, 330 Cedar Street, FMP107, New Haven, CT 06510, USA.

Primary Care
|May 20, 2008
PubMed
Summary

This review covers six systemic diseases with common kidney problems: diabetic nephropathy, lupus nephritis, heart failure, HIV, liver disease, and dysproteinemias. Early recognition and management are key for improving patient renal outcomes.

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Last Updated: Jul 5, 2026

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

  • Nephrology
  • Internal Medicine
  • Systemic Diseases

Background:

  • Systemic diseases frequently manifest with renal involvement, impacting kidney function and patient prognosis.
  • Understanding these associations is crucial for timely diagnosis and effective management.
  • Six key systemic diseases with significant renal implications are discussed.

Purpose of the Study:

  • To review the epidemiology, recognition, screening, and management of common systemic diseases presenting with renal manifestations.
  • To highlight the current understanding and prognosis of these kidney-related conditions.

Main Methods:

  • Literature review focusing on epidemiological data, clinical recognition, diagnostic screening, and therapeutic strategies.
  • Synthesis of current knowledge on diabetic nephropathy, lupus nephritis, HIV-associated nephropathy, kidney disease in liver disease, and dysproteinemias.

Main Results:

  • Diabetic nephropathy is the primary cause of end-stage renal disease in the US.
  • Prognosis for lupus nephritis and HIV-associated nephropathy has improved.
  • Renal function estimation in advanced liver disease requires non-creatinine-based methods.
  • Dysproteinemias can present with diverse renal manifestations, sometimes as the initial sign.

Conclusions:

  • Effective management of systemic diseases is vital for preserving renal health.
  • Continued research and updated guidelines are necessary for optimizing care in these complex patient populations.
  • Awareness of renal manifestations aids in early detection and intervention for systemic illnesses.